Different boundaries characterize isolated and non-isolated 5q deletions in myelodysplastic syndromes and acute myeloid leukemias.

نویسندگان

  • Valeria Nofrini
  • Roberta La Starza
  • Barbara Crescenzi
  • Valentina Pierini
  • Gianluca Barba
  • Cristina Mecucci
چکیده

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منابع مشابه

Biological and prognostic significance of chromosome 5q deletions in myeloid malignancies.

The presence of del(5q), either as the sole karyotypic abnormality or as part of a more complex karyotype, has distinct clinical implications for myelodysplastic syndromes (MDS) and acute myeloid leukemia. The 5q- syndrome, a subtype of low-risk MDS, is characterized by an isolated 5q deletion and <5% blasts in the bone marrow and can serve as a useful model for studying the role of 5q deletion...

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Submicroscopic deletions in 5q- associated malignancies.

BACKGROUND AND OBJECTIVES The deletion of the long arm of chromosome 5 is common in myelodysplastic syndromes (MDS) but is not limited to the 5q- syndrome as it is also seen in acute myeloid leukemia (AML), where it is often associated with other karyotypic aberrations. The aim of this study was to investigate whether deletions of known suppressor sequences occur in myeloid malignancies associa...

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Clonal evolution in myelodysplastic syndromes with isolated del(5q): the importance of genetic monitoring.

Myelodysplastic syndromes (MDS) with isolated deletion of chromosome arm 5q (del(5q)) have a good prognosis with low risk of transformation to acute myeloid leukemia (AML). Laboratory investigations typically demonstrate macrocytic anemia with preserved or increased platelet counts, and characteristic hypolobated megakaryocytes in the marrow (Figure 1A). Recent studies have provided significant...

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Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level.

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders characterized by ineffective hematopoiesis and frequent progression to acute myeloid leukemia. Within MDS, 5q- syndrome constitutes a distinct clinical entity characterized by an isolated deletion of the long arm of chromosome 5 (5q-), a relatively good prognosis, and infrequent transformation to acute leukemia. The c...

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Human Cancer Biology Profiling Three-Dimensional Nuclear Telomeric Architecture of Myelodysplastic Syndromes and Acute Myeloid Leukemia Defines Patient Subgroups

Purpose:Myelodysplastic syndromes (MDS) are a group of disorders characterized by cytopenias, with a propensity for evolution into acute myeloid leukemias (AML). This transformation is driven by genomic instability, but mechanisms remain unknown. Telomere dysfunction might generate genomic instability leading to cytopenias and disease progression. Experimental Design:We undertook a pilot study ...

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عنوان ژورنال:
  • Haematologica

دوره 97 5  شماره 

صفحات  -

تاریخ انتشار 2012